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1994-10-25
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Document 2942
DOCN M94A2942
TI First HIV-1 positive diagnosis coincident with AIDS: presentation and
prognosis.
DT 9412
AU Poznansky MC; Coker R; Skinner C; Bailey S; Renton A; Weber J; St Mary's
Hospital, London, U.K.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):19 (abstract no. 051B). Unique
Identifier : AIDSLINE ICA10/94369633
AB OBJECTIVE: Between January 1991 and December 1992, 61/281 (22%) of the
patients presenting with their first AIDS defining illness to the
Genito-Urinary Medicine Dept. at St Mary's Hospital in London had not
previously been diagnosed as being HIV-1 positive. This study sought to
determine whether late presenters with HIV-1 infection and AIDS (Group
B) differed from patients who tested HIV-1 positive within the previous
8 years, and who were followed up in out-patient clinics prior to
developing AIDS (Group A). METHODS: The clinical details, haematological
and immunological parameters and survival of patients from the time of
their first AIDS defining illness were noted. RESULTS: The spectrum of
first AIDS defining illnesses in the two groups was similar with the
exception of extra-pulmonary TB which was more common in Group B. The
two groups did not differ in age, sex, risk factors for HIV-1 infection,
nationality, county of origin or relevant haematological parameters and
CD4-positive lymphocyte count determined at the time of the first AIDS
defining illness. There was no significant difference between the
proportion of patients in each group who died within 6, 12 and 24 months
of their AIDS diagnosis. DISCUSSION: Late presenters progress from
asymptomatic HIV infection to AIDS in the absence of health advice and
without anti-retroviral drugs or PCP prophylaxis. These patients
challenge the epidemiological control of HIV-1 and generate new
questions concerning the impact of early intervention for HIV-1
infection, in relation to survival after their first AIDS defining
illness.
DE Acquired Immunodeficiency Syndrome/*DIAGNOSIS/DRUG THERAPY/ MORTALITY
Adult Antiviral Agents/THERAPEUTIC USE Female Human HIV
Infections/*DIAGNOSIS/MICROBIOLOGY *HIV-1 Male Prognosis Time
Factors MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).